فَاعْبُدُوا مَا شِيْتُم مِّن دُونِهِSay:"Allah Alone I worship by doing religious deeds sincerely for His sake only. So, worship what you like besides Him."This is also a threat, and a disowning of them.قُلْ إِنَّ الْخَاسِرِينَSay:"The losers..."means, the greatest losers of all,الَّذِينَ خَسِرُوا أَنفُسَهُمْ وَأَهْلِيهِمْ يَوْمَ الْقِيَامَةِare those who will lose themselves and their families on the Day of Resurrection.means, they will be separated and will never meet again, whether their families have gone to Paradise and they have gone to Hell, or all of them have gone to Hell, they will never meet or feel happiness again.أَلَا ذَلِكَ هُوَ الْخُسْرَانُ الْمُبِينُVerily, that will be a manifest loss!means, this is the clearest and most obvious loss.Then He describes their state in the Fire