أُوْلَـيِكَ الَّذِينَ خَسِرُواْ أَنفُسَهُمْThey are those who have lost their own selves,They lost themselves, meaning that they be made to enter a blazing Fire, where they will be punished, and its torment will not be lifted from them for even the blinking of an eye.This is as Allah said,كُلَّمَا خَبَتْ زِدْنَاهُمْ سَعِيرًاWhenever it abates, We shall increase for them the fierceness of the Fire. (17:97)Concerning the statement,وَضَلَّ عَنْهُمand eluded them,meaning that it has left them.مَّا كَانُواْ يَفْتَرُونَthat which they invented.besides Allah, such as rivals and idols. Yet, these things did not avail them in the slightest. In fact, these things actually caused them great harm.This is as Allah says,وَإِذَا حُشِرَ النَّاسُ كَانُواْ لَهُمْ أَعْدَاءً وَكَانُواْ بِعِبَادَتِهِمْ كَـفِرِينَAnd when mankind are gathered, they will become their enemies and will deny their worshipping. (46:6) Allah says,إِذْ تَبَرَّأَ الَّذِينَ اتُّبِعُواْ مِنَ الَّذِينَ اتَّبَعُواْ وَرَأَوُاْ الْعَذَابَ وَتَقَطَّعَتْ بِهِمُ الاٌّسْبَابُWhen those who were followed disown those who followed (them), and they see the torment, then all their relations will be cut off from them. (2:166)Likewise, there are many other verses that prove this loss of theirs and their destruction.For this reason Allah says,لَا جَرَمَ أَنَّهُمْ فِي الااخِرَةِ هُمُ الَاخْسَرُونَ